This article describes the dataset of the Kolyma Water-Balance Station located at the upstreams of the Kolyma River (Russia). The dataset combines continuous long-term (1948–1997) observations of water balance, hydrological processes, and permafrost. It allows for study of permafrost hydrology interaction processes in a practically unexplored region. We highlight the main historical stages of the station's existence and its scientific significance, and outline the prospects for its future.